https://doi.org/10.4081/mem.2018.540
Clinical and ethical use of induced pluripotent stem cells / Uso clinico ed etico delle cellule pluripotenti indotte
Ricevuto: luglio 30, 2018
Accettato: luglio 30, 2018
Pubblicato: luglio 30, 2018
Accettato: luglio 30, 2018
Abstract Views: 962
PDF: 7
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Autori
Since its discovery, more than a decade ago, induced pluripotent stem cells (iPS) have had a prominent relevance in the environments of biomedical research and, at the same time, their origin has been related to the search for an ethical alternative to use of the stem cells obtained from internal mass of the human embryo. In this article we intend to give an overview of its possible applications in the advancement of biomedicine and its relationship with bioethics. From its possible application to regenerate tissues, after proceeding to their differentiation; testing of drugs for different conditions; or their use in models of diseases, among which the neurological ones stand out. Also, its application in obtaining germ cells and human embryos. The situation of the first clinical trial to regenerate a tissue from the subject's own iPS cells, and the recent allogeneic transplantation in Japan, suggest advances in the clinical translation of these cells. On the other hand, the production of germ cells from iPS cells and the new cells called extended pluripotent stem cells (EPS), obtained by genetic reprogramming through a chemical cocktail, that give rise not only to the tissues of the embryonic layers, but also extra- embryonic, are a new path to making clonation by another route.----------Fin dalla sua scoperta, per oltre un decennio, cellule staminali pluripotenti indotte (iPS) hanno un'importanza notevole nella ricerca biomedica ambienti e, allo stesso tempo, la sua origine è legata alla ricerca di un'alternativa etica all'utilizzo le cellule staminali ottenute dalla massa interna dell'embrione umano. In questo articolo diamo una panoramica delle possibili applicazioni nell'avanzamento biomedicina e la loro relazione bioetica. Dalla sua possibile applicazione di rigenerare il tessuto, quindi procedere alla differenziazione; la sperimentazione di farmaci per diversi disturbi; o il suo uso in modelli di malattie, tra cui spiccano quelle neurologiche. Così come la sua applicazione nell'ottenere cellule germinali e embrioni umani. La situazione del primo studio clinico per rigenerare un tessuto da cellule iPS e proprio trapianto recente del soggetto in Giappone rappresentano passi nella traduzione clinica di queste cellule. Inoltre la produzione di cellule germinali dalle cellule iPS e nuove cellule chiamate cellule staminali pluripotenti estesi (EPS), riprogrammando geneticamente da un cocktail chimico, causando non solo ai tessuti degli strati embrionali, ma extraembrionali anche costituire un nuovo percorso verso la clonazione di un altro itinerario.
Come citare
Millás-Mur, J. (2018). Clinical and ethical use of induced pluripotent stem cells / Uso clinico ed etico delle cellule pluripotenti indotte. Medicina E Morale, 67(3), 291–305. https://doi.org/10.4081/mem.2018.540
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